Drug interactions
Brexanolone + Risperidone
Severity: Moderate
Brexanolone and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and sudden loss of consciousness, and risperidone also has sedating properties. Used together, excessive sedation may be more likely.
What this interaction means in plain words
Brexanolone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic effects (GABA-A modulation plus antipsychotic sedation).
What to do
Monitor continuously for sedation and hypoxia during the brexanolone infusion, as per labeling. Interrupt or reduce the infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Brexanolone with Risperidone?
MediHelp rates the interaction as moderate. Brexanolone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and sudden loss of consciousness, and risperidone also has sedating properties. Used together, excessive sedation may be more likely.
How serious is the interaction between Brexanolone and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the brexanolone infusion, as per labeling. Interrupt or reduce the infusion if excessive sedation occurs.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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