Drug interactions
Brexanolone + Sevoflurane
Severity: Moderate
Brexanolone and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone is a neuroactive steroid that causes excessive sedation and loss of consciousness, and it would add to the effects of sevoflurane. Deeper sedation and respiratory depression are expected.
What this interaction means in plain words
Brexanolone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive enhancement of GABA-A receptor mediated CNS depression.
What to do
Monitor sedation level and oxygen saturation and reduce anesthetic doses as needed. Consider timing elective anesthesia away from brexanolone infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Brexanolone with Sevoflurane?
MediHelp rates the interaction as moderate. Brexanolone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone is a neuroactive steroid that causes excessive sedation and loss of consciousness, and it would add to the effects of sevoflurane. Deeper sedation and respiratory depression are expected.
How serious is the interaction between Brexanolone and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and oxygen saturation and reduce anesthetic doses as needed. Consider timing elective anesthesia away from brexanolone infusion.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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