Drug interactions
Brexpiprazole + Clonazepam
Severity: Moderate
Brexpiprazole and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taken together, these drugs can increase drowsiness, dizziness and impaired alertness. Orthostatic hypotension may also be additive.
What this interaction means in plain words
Brexpiprazole and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and the sedative receptor profile of brexpiprazole.
What to do
Monitor for oversedation and orthostasis, particularly at initiation and with dose increases. Warn patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Clonazepam?
MediHelp rates the interaction as moderate. Brexpiprazole and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taken together, these drugs can increase drowsiness, dizziness and impaired alertness. Orthostatic hypotension may also be additive.
How serious is the interaction between Brexpiprazole and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostasis, particularly at initiation and with dose increases. Warn patients about driving and alcohol.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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