Drug interactions
Brexpiprazole + Cyclosporin
Severity: Moderate
Brexpiprazole and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine is a CYP3A4 and P-glycoprotein inhibitor and may modestly raise brexpiprazole exposure. The effect is greatest when CYP2D6 is also inhibited or in CYP2D6 poor metabolizers, increasing the risk of sedation, akathisia and other adverse effects.
What this interaction means in plain words
Brexpiprazole and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Cyclosporin belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of brexpiprazole.
What to do
Monitor for adverse effects of brexpiprazole and reduce its dose if a strong CYP2D6 inhibitor or poor-metabolizer status is also present, following labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Cyclosporin?
MediHelp rates the interaction as moderate. Brexpiprazole and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine is a CYP3A4 and P-glycoprotein inhibitor and may modestly raise brexpiprazole exposure. The effect is greatest when CYP2D6 is also inhibited or in CYP2D6 poor metabolizers, increasing the risk of sedation, akathisia and other adverse effects.
How serious is the interaction between Brexpiprazole and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of brexpiprazole and reduce its dose if a strong CYP2D6 inhibitor or poor-metabolizer status is also present, following labeling.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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