Drug interactions
Brexpiprazole + Diazepam
Severity: Moderate
Brexpiprazole and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen drowsiness and impair psychomotor performance and alertness. Falls and accidents are the main practical concerns, particularly in older patients.
What this interaction means in plain words
Brexpiprazole and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression through GABA-A potentiation by diazepam and antagonism of histaminergic and adrenergic receptors by brexpiprazole.
What to do
Start with the lowest effective doses and monitor for excessive sedation, dizziness and falls. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Diazepam?
MediHelp rates the interaction as moderate. Brexpiprazole and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen drowsiness and impair psychomotor performance and alertness. Falls and accidents are the main practical concerns, particularly in older patients.
How serious is the interaction between Brexpiprazole and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor for excessive sedation, dizziness and falls. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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