Drug interactions
Brexpiprazole + Dimenhydrinate
Severity: Moderate
Brexpiprazole and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate, which contains diphenhydramine, is sedating, and brexpiprazole also causes somnolence. Combined use may increase drowsiness and impair alertness.
What this interaction means in plain words
Brexpiprazole and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depression via H1 antagonism and antipsychotic sedation.
What to do
Warn the patient about additive drowsiness and avoid driving if impaired. Consider a less sedating antiemetic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Brexpiprazole with Dimenhydrinate?
MediHelp rates the interaction as moderate. Brexpiprazole and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate, which contains diphenhydramine, is sedating, and brexpiprazole also causes somnolence. Combined use may increase drowsiness and impair alertness.
How serious is the interaction between Brexpiprazole and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about additive drowsiness and avoid driving if impaired. Consider a less sedating antiemetic if possible.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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