Drug interactions
Brexpiprazole + Diphenoxylate-atropine
Severity: Moderate
Brexpiprazole and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid and brexpiprazole is a sedating antipsychotic, so together they may increase drowsiness and impair psychomotor performance. Risk is greatest with higher doses or in older patients.
What this interaction means in plain words
Brexpiprazole and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression.
What to do
Counsel patients about drowsiness and avoid driving until response is known; use the lowest effective antidiarrheal dose and for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Brexpiprazole and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid and brexpiprazole is a sedating antipsychotic, so together they may increase drowsiness and impair psychomotor performance. Risk is greatest with higher doses or in older patients.
How serious is the interaction between Brexpiprazole and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoid driving until response is known; use the lowest effective antidiarrheal dose and for the shortest time.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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