Drug interactions
Brexpiprazole + Empagliflozin-metformin
Severity: Moderate
Brexpiprazole and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause hyperglycemia and weight gain, which may reduce diabetes control. The effect is generally modest but relevant in patients with established diabetes.
What this interaction means in plain words
Brexpiprazole and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: atypical antipsychotics can impair insulin sensitivity and glucose metabolism.
What to do
Monitor glucose and HbA1c at the start of brexpiprazole and periodically after, adjusting antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Brexpiprazole and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause hyperglycemia and weight gain, which may reduce diabetes control. The effect is generally modest but relevant in patients with established diabetes.
How serious is the interaction between Brexpiprazole and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c at the start of brexpiprazole and periodically after, adjusting antidiabetic therapy if control worsens.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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