Drug interactions
Brexpiprazole + Imipramine
Severity: Moderate
Brexpiprazole and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine may inhibit CYP2D6 weakly and could raise brexpiprazole concentrations, while both drugs cause sedation. The result may be more drowsiness, orthostasis or other adverse effects.
What this interaction means in plain words
Brexpiprazole and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Possible CYP2D6 inhibition raising brexpiprazole exposure, plus additive CNS depression.
What to do
Monitor for sedation and orthostatic hypotension. Reduce the brexpiprazole dose if adverse effects occur, particularly if a CYP3A4 inhibitor is also being given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Imipramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine may inhibit CYP2D6 weakly and could raise brexpiprazole concentrations, while both drugs cause sedation. The result may be more drowsiness, orthostasis or other adverse effects.
How serious is the interaction between Brexpiprazole and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension. Reduce the brexpiprazole dose if adverse effects occur, particularly if a CYP3A4 inhibitor is also being given.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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