Drug interactions
Brexpiprazole + Ivosidenib
Severity: Moderate
Brexpiprazole and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower brexpiprazole concentrations, risking reduced antipsychotic or adjunctive antidepressant effect. The loss of effect may be gradual and easily missed.
What this interaction means in plain words
Brexpiprazole and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction by ivosidenib increases brexpiprazole metabolism.
What to do
Monitor for loss of efficacy and consider increasing the brexpiprazole dose, up to about double the usual dose as labeling advises for strong inducers; reduce it again when ivosidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Brexpiprazole with Ivosidenib?
MediHelp rates the interaction as moderate. Brexpiprazole and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower brexpiprazole concentrations, risking reduced antipsychotic or adjunctive antidepressant effect. The loss of effect may be gradual and easily missed.
How serious is the interaction between Brexpiprazole and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider increasing the brexpiprazole dose, up to about double the usual dose as labeling advises for strong inducers; reduce it again when ivosidenib is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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