Drug interactions
Brexpiprazole + Larotrectinib
Severity: Minor
Brexpiprazole and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor and might slightly increase brexpiprazole exposure. A clinically meaningful effect is not expected.
What this interaction means in plain words
Brexpiprazole and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by larotrectinib may modestly reduce brexpiprazole metabolism.
What to do
No dose adjustment is needed; watch for sedation or akathisia and adjust the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Larotrectinib
Frequently asked questions
Can I take Brexpiprazole with Larotrectinib?
MediHelp rates the interaction as minor. Brexpiprazole and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor and might slightly increase brexpiprazole exposure. A clinically meaningful effect is not expected.
How serious is the interaction between Brexpiprazole and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; watch for sedation or akathisia and adjust the dose if they occur.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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