Drug interactions
Brexpiprazole + Lidocaine
Severity: Minor
Brexpiprazole and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is a weak inhibitor of CYP2D6 and CYP3A4, so systemic exposure to brexpiprazole could rise slightly. The effect is expected to be small, since brexpiprazole dose reduction is advised only with combined strong or moderate inhibitors of both pathways.
What this interaction means in plain words
Brexpiprazole and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Lidocaine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2D6 and CYP3A4 by lidocaine reduces brexpiprazole clearance.
What to do
No routine dose change is needed; monitor for brexpiprazole adverse effects such as akathisia or sedation if prolonged systemic lidocaine is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Lidocaine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Lidocaine?
MediHelp rates the interaction as minor. Brexpiprazole and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is a weak inhibitor of CYP2D6 and CYP3A4, so systemic exposure to brexpiprazole could rise slightly. The effect is expected to be small, since brexpiprazole dose reduction is advised only with combined strong or moderate inhibitors of both pathways.
How serious is the interaction between Brexpiprazole and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for brexpiprazole adverse effects such as akathisia or sedation if prolonged systemic lidocaine is used.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
