Drug interactions
Brexpiprazole + Lorazepam
Severity: Moderate
Brexpiprazole and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause somnolence and dizziness, and lorazepam adds to these effects. Alertness and coordination may be reduced.
What this interaction means in plain words
Brexpiprazole and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through antipsychotic receptor effects and GABA-A potentiation.
What to do
Monitor for sedation and orthostasis, and advise caution with driving until the response is known. Reduce the dose of either agent if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Lorazepam?
MediHelp rates the interaction as moderate. Brexpiprazole and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause somnolence and dizziness, and lorazepam adds to these effects. Alertness and coordination may be reduced.
How serious is the interaction between Brexpiprazole and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostasis, and advise caution with driving until the response is known. Reduce the dose of either agent if drowsiness is excessive.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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