Drug interactions
Brexpiprazole + Lorlatinib
Severity: Moderate
Brexpiprazole and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A4 inducer and may lower brexpiprazole concentrations, because brexpiprazole is cleared in part by CYP3A4. This could reduce antipsychotic efficacy and risk relapse.
What this interaction means in plain words
Brexpiprazole and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 induction by lorlatinib increases brexpiprazole metabolism.
What to do
Monitor for loss of psychiatric symptom control and consider increasing the brexpiprazole dose. Reassess the dose if lorlatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Lorlatinib?
MediHelp rates the interaction as moderate. Brexpiprazole and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A4 inducer and may lower brexpiprazole concentrations, because brexpiprazole is cleared in part by CYP3A4. This could reduce antipsychotic efficacy and risk relapse.
How serious is the interaction between Brexpiprazole and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric symptom control and consider increasing the brexpiprazole dose. Reassess the dose if lorlatinib is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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