Drug interactions
Brexpiprazole + Metformin-pioglitazone
Severity: Moderate
Brexpiprazole and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause hyperglycemia and weight gain, potentially worsening glycemic control in patients with diabetes.
What this interaction means in plain words
Brexpiprazole and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Atypical antipsychotic effects on insulin sensitivity and glucose regulation oppose antidiabetic therapy.
What to do
Monitor fasting glucose and HbA1c after initiation and periodically, adjusting antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Brexpiprazole and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause hyperglycemia and weight gain, potentially worsening glycemic control in patients with diabetes.
How serious is the interaction between Brexpiprazole and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after initiation and periodically, adjusting antidiabetic therapy as needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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