Drug interactions
Brexpiprazole + Netupitant-palonosetron
Severity: Moderate
Brexpiprazole and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a moderate CYP3A4 inhibitor and may raise brexpiprazole exposure, with greater effect if a CYP2D6 inhibitor is also present. Higher levels can increase sedation, akathisia, and other adverse effects. With a single-dose antiemetic regimen the effect is generally limited.
What this interaction means in plain words
Brexpiprazole and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4-mediated brexpiprazole metabolism by netupitant.
What to do
Monitor for adverse effects of brexpiprazole after netupitant. Reduce the brexpiprazole dose to a quarter if the patient also takes a CYP2D6 inhibitor, as labeled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Brexpiprazole and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant is a moderate CYP3A4 inhibitor and may raise brexpiprazole exposure, with greater effect if a CYP2D6 inhibitor is also present. Higher levels can increase sedation, akathisia, and other adverse effects. With a single-dose antiemetic regimen the effect is generally limited.
How serious is the interaction between Brexpiprazole and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of brexpiprazole after netupitant. Reduce the brexpiprazole dose to a quarter if the patient also takes a CYP2D6 inhibitor, as labeled.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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