Drug interactions
Brexpiprazole + Nortriptyline
Severity: Moderate
Brexpiprazole and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and orthostatic hypotension, so combining them can reduce alertness and increase falls. Nortriptyline may also modestly increase brexpiprazole exposure as brexpiprazole is partly metabolized by CYP2D6.
What this interaction means in plain words
Brexpiprazole and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension, with possible minor CYP2D6 competition.
What to do
Monitor sedation and blood pressure and counsel on driving. Adjust doses if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Nortriptyline?
MediHelp rates the interaction as moderate. Brexpiprazole and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and orthostatic hypotension, so combining them can reduce alertness and increase falls. Nortriptyline may also modestly increase brexpiprazole exposure as brexpiprazole is partly metabolized by CYP2D6.
How serious is the interaction between Brexpiprazole and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure and counsel on driving. Adjust doses if adverse effects emerge.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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