Drug interactions
Brexpiprazole + Oxcarbazepine
Severity: Moderate
Brexpiprazole and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak to moderate CYP3A4 inducer and may reduce brexpiprazole levels. This could reduce therapeutic effect.
What this interaction means in plain words
Brexpiprazole and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, increasing brexpiprazole clearance.
What to do
Monitor clinical response and raise the brexpiprazole dose if symptoms worsen. Reassess dosing when oxcarbazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Brexpiprazole with Oxcarbazepine?
MediHelp rates the interaction as moderate. Brexpiprazole and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak to moderate CYP3A4 inducer and may reduce brexpiprazole levels. This could reduce therapeutic effect.
How serious is the interaction between Brexpiprazole and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and raise the brexpiprazole dose if symptoms worsen. Reassess dosing when oxcarbazepine is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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