Drug interactions
Brexpiprazole + Suvorexant
Severity: Moderate
Brexpiprazole and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is an orexin antagonist hypnotic and can add to brexpiprazole's sedating effects. This may cause next-day drowsiness and impaired driving or coordination.
What this interaction means in plain words
Brexpiprazole and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and antipsychotic sedation.
What to do
Use the lowest effective suvorexant dose and warn patients about next-day impairment. Monitor for excessive daytime sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Suvorexant
Frequently asked questions
Can I take Brexpiprazole with Suvorexant?
MediHelp rates the interaction as moderate. Brexpiprazole and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is an orexin antagonist hypnotic and can add to brexpiprazole's sedating effects. This may cause next-day drowsiness and impaired driving or coordination.
How serious is the interaction between Brexpiprazole and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and warn patients about next-day impairment. Monitor for excessive daytime sedation.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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