Drug interactions
Brexucabtagene autoleucel + Vedolizumab
Severity: Moderate
Brexucabtagene autoleucel and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vedolizumab acts selectively on the gut, so systemic immunosuppression is limited, but CAR T therapy causes prolonged cytopenias and hypogammaglobulinemia. Added gut-directed immune suppression could modestly raise infection risk, particularly gastrointestinal.
What this interaction means in plain words
Brexucabtagene autoleucel and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexucabtagene autoleucel belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immune suppression from gut-selective integrin blockade and CAR T-related immune depletion.
What to do
Review the need for vedolizumab around CAR T therapy with the treating team. Monitor for infection, especially gastrointestinal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Brexucabtagene autoleucel
Frequently asked questions
Can I take Brexucabtagene autoleucel with Vedolizumab?
MediHelp rates the interaction as moderate. Brexucabtagene autoleucel and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vedolizumab acts selectively on the gut, so systemic immunosuppression is limited, but CAR T therapy causes prolonged cytopenias and hypogammaglobulinemia. Added gut-directed immune suppression could modestly raise infection risk, particularly gastrointestinal.
How serious is the interaction between Brexucabtagene autoleucel and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for vedolizumab around CAR T therapy with the treating team. Monitor for infection, especially gastrointestinal.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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