Drug interactions
Brigatinib + Cyclosporin
Severity: Moderate
Brigatinib and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 and lower cyclosporine concentrations, which could lead to loss of immunosuppression and graft rejection or other treatment failure.
What this interaction means in plain words
Brigatinib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Brigatinib induces CYP3A4, increasing cyclosporine metabolism (mainly an in vitro finding).
What to do
Monitor cyclosporine trough levels after starting or stopping brigatinib and adjust the cyclosporine dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Cyclosporin?
MediHelp rates the interaction as moderate. Brigatinib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib may induce CYP3A4 and lower cyclosporine concentrations, which could lead to loss of immunosuppression and graft rejection or other treatment failure.
How serious is the interaction between Brigatinib and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels after starting or stopping brigatinib and adjust the cyclosporine dose as required.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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