Drug interactions
Brigatinib + Quinine
Severity: Moderate
Brigatinib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4, which could lower quinine exposure and reduce its antimalarial efficacy. This is based mainly on in vitro induction data and a well-understood quinine clearance pathway.
What this interaction means in plain words
Brigatinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Brigatinib induction of CYP3A4 increases the metabolism of quinine.
What to do
Monitor for treatment failure when quinine is used for malaria, and consider an alternative antimalarial if feasible. Avoid relying on quinine for prophylaxis in this setting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Quinine?
MediHelp rates the interaction as moderate. Brigatinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib may induce CYP3A4, which could lower quinine exposure and reduce its antimalarial efficacy. This is based mainly on in vitro induction data and a well-understood quinine clearance pathway.
How serious is the interaction between Brigatinib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure when quinine is used for malaria, and consider an alternative antimalarial if feasible. Avoid relying on quinine for prophylaxis in this setting.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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