Drug interactions
Brimonidine + Cinnarizine
Severity: Minor
Brimonidine and Cinnarizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops can cause drowsiness and fatigue, and cinnarizine is a sedating antihistamine. Together they may add to sedation, although systemic absorption of the ophthalmic drug is low so the effect is usually modest.
What this interaction means in plain words
Brimonidine and Cinnarizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Cinnarizine belongs to Respiratory.
Why it happens
Additive CNS depressant effects from central alpha-2 agonism and H1 antihistamine sedation.
What to do
Warn patients about possible drowsiness and advise caution when driving or operating machinery until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Brimonidine with Cinnarizine?
MediHelp rates the interaction as minor. Brimonidine and Cinnarizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops can cause drowsiness and fatigue, and cinnarizine is a sedating antihistamine. Together they may add to sedation, although systemic absorption of the ophthalmic drug is low so the effect is usually modest.
How serious is the interaction between Brimonidine and Cinnarizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about possible drowsiness and advise caution when driving or operating machinery until the response is known.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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