Drug interactions
Brimonidine + Clobazam
Severity: Moderate
Brimonidine and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine that causes sedation and psychomotor impairment. Brimonidine may add to drowsiness, increasing the risk of oversedation and falls.
What this interaction means in plain words
Brimonidine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and alpha-2 agonism.
What to do
Monitor for excessive sedation, especially in older adults, and advise against driving until tolerance is established. Lower the dose of one agent if sedation is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Brimonidine with Clobazam?
MediHelp rates the interaction as moderate. Brimonidine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine that causes sedation and psychomotor impairment. Brimonidine may add to drowsiness, increasing the risk of oversedation and falls.
How serious is the interaction between Brimonidine and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, especially in older adults, and advise against driving until tolerance is established. Lower the dose of one agent if sedation is problematic.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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