Drug interactions
Brimonidine + Clomipramine
Severity: Minor
Brimonidine and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine, particularly as an ophthalmic solution, is minimally absorbed systemically, but systemic alpha-2 agonist exposure can cause drowsiness. With clomipramine, sedation could theoretically be additive.
What this interaction means in plain words
Brimonidine and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression; brimonidine is a central alpha-2 agonist.
What to do
Usually no action is needed with ophthalmic brimonidine; advise patients to watch for excess drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Clomipramine?
MediHelp rates the interaction as minor. Brimonidine and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine, particularly as an ophthalmic solution, is minimally absorbed systemically, but systemic alpha-2 agonist exposure can cause drowsiness. With clomipramine, sedation could theoretically be additive.
How serious is the interaction between Brimonidine and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no action is needed with ophthalmic brimonidine; advise patients to watch for excess drowsiness.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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