Drug interactions
Brimonidine + Clorazepate
Severity: Minor
Brimonidine and Clorazepate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops have minimal systemic absorption, but some systemic exposure occurs and it can cause drowsiness, so a small additive effect with clorazepate is possible. The clinical significance is usually limited.
What this interaction means in plain words
Brimonidine and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Clorazepate belongs to Central Nervous System.
Why it happens
Possible additive CNS depression from central alpha-2 agonism of absorbed brimonidine and benzodiazepine GABAergic effects.
What to do
No routine change is needed. Warn patients, especially older adults, that drowsiness may increase and advise caution with driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Clorazepate?
MediHelp rates the interaction as minor. Brimonidine and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops have minimal systemic absorption, but some systemic exposure occurs and it can cause drowsiness, so a small additive effect with clorazepate is possible. The clinical significance is usually limited.
How serious is the interaction between Brimonidine and Clorazepate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Warn patients, especially older adults, that drowsiness may increase and advise caution with driving.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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