Drug interactions
Brimonidine + Iloperidone
Severity: Moderate
Brimonidine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone can cause sedation, somnolence and orthostatic hypotension. Brimonidine may add to drowsiness.
What this interaction means in plain words
Brimonidine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from antipsychotic receptor antagonism and alpha-2 agonism.
What to do
Monitor for sedation and orthostatic symptoms, and advise caution with driving. Adjust doses if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Brimonidine with Iloperidone?
MediHelp rates the interaction as moderate. Brimonidine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone can cause sedation, somnolence and orthostatic hypotension. Brimonidine may add to drowsiness.
How serious is the interaction between Brimonidine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, and advise caution with driving. Adjust doses if sedation is excessive.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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