Drug interactions
Brimonidine + Labetalol
Severity: Minor
Brimonidine and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops are absorbed to a small degree and can lower heart rate and blood pressure. Additive hypotension or bradycardia with labetalol is possible but typically minor.
What this interaction means in plain words
Brimonidine and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Labetalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic lowering of blood pressure and heart rate through central sympatholytic action.
What to do
Monitor blood pressure and heart rate in susceptible patients. No routine adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Labetalol?
MediHelp rates the interaction as minor. Brimonidine and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops are absorbed to a small degree and can lower heart rate and blood pressure. Additive hypotension or bradycardia with labetalol is possible but typically minor.
How serious is the interaction between Brimonidine and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate in susceptible patients. No routine adjustment is needed.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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