Drug interactions
Brimonidine + Losartan
Severity: Minor
Brimonidine and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops are absorbed systemically to a small extent and can lower blood pressure, but the effect is minimal in most patients. Additive hypotension with losartan is possible but unlikely to be clinically significant.
What this interaction means in plain words
Brimonidine and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Losartan belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism and angiotensin receptor blockade.
What to do
No routine action is needed; check blood pressure if the patient reports dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Losartan?
MediHelp rates the interaction as minor. Brimonidine and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops are absorbed systemically to a small extent and can lower blood pressure, but the effect is minimal in most patients. Additive hypotension with losartan is possible but unlikely to be clinically significant.
How serious is the interaction between Brimonidine and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check blood pressure if the patient reports dizziness.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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