Drug interactions
Brimonidine + Metoprolol
Severity: Minor
Brimonidine and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops are absorbed to a small extent and can modestly lower blood pressure and heart rate. In patients on metoprolol this could add slightly to hypotension or bradycardia, but a clinically important effect is uncommon.
What this interaction means in plain words
Brimonidine and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Metoprolol belongs to Cardiovascular.
Why it happens
Possible additive hypotensive and bradycardic effects from systemic alpha-2 agonism combined with beta-blockade.
What to do
No routine change is needed; check pulse and blood pressure if the patient reports dizziness or fatigue after starting brimonidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Metoprolol?
MediHelp rates the interaction as minor. Brimonidine and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops are absorbed to a small extent and can modestly lower blood pressure and heart rate. In patients on metoprolol this could add slightly to hypotension or bradycardia, but a clinically important effect is uncommon.
How serious is the interaction between Brimonidine and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check pulse and blood pressure if the patient reports dizziness or fatigue after starting brimonidine.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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