Drug interactions
Brimonidine + Midazolam
Severity: Minor
Brimonidine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can cause drowsiness and lowered blood pressure, especially systemically absorbed from ophthalmic use in children. With midazolam, additive sedation is possible, although exposure from eye drops in adults is usually small.
What this interaction means in plain words
Brimonidine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression from central alpha-2 agonism and GABA-A potentiation.
What to do
Monitor sedation, particularly in children or when midazolam is used for procedural sedation. No routine dose change is needed in adults.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Midazolam?
MediHelp rates the interaction as minor. Brimonidine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can cause drowsiness and lowered blood pressure, especially systemically absorbed from ophthalmic use in children. With midazolam, additive sedation is possible, although exposure from eye drops in adults is usually small.
How serious is the interaction between Brimonidine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, particularly in children or when midazolam is used for procedural sedation. No routine dose change is needed in adults.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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