Drug interactions
Brimonidine + Tizanidine
Severity: Minor
Brimonidine and Tizanidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist, and although used as eye drops it is absorbed systemically enough to cause drowsiness and hypotension in some patients. Combined with oral tizanidine, which has the same pharmacologic action, additive sedation and lowered blood pressure are possible.
What this interaction means in plain words
Brimonidine and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive central alpha-2 adrenergic agonism producing sedation and hypotension.
What to do
Usually no change is needed; counsel patients about drowsiness and check blood pressure if dizziness occurs, particularly in the elderly or with systemic brimonidine formulations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Tizanidine?
MediHelp rates the interaction as minor. Brimonidine and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist, and although used as eye drops it is absorbed systemically enough to cause drowsiness and hypotension in some patients. Combined with oral tizanidine, which has the same pharmacologic action, additive sedation and lowered blood pressure are possible.
How serious is the interaction between Brimonidine and Tizanidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; counsel patients about drowsiness and check blood pressure if dizziness occurs, particularly in the elderly or with systemic brimonidine formulations.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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