Drug interactions
Brivaracetam + Rucaparib
Severity: Minor
Brivaracetam and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C19 and may modestly raise brivaracetam levels. The clinical effect is likely small.
What this interaction means in plain words
Brivaracetam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brivaracetam belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP2C19-mediated brivaracetam metabolism by rucaparib.
What to do
No routine adjustment is needed; monitor for dizziness and sedation and reduce the brivaracetam dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brivaracetam
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Brivaracetam with Rucaparib?
MediHelp rates the interaction as minor. Brivaracetam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C19 and may modestly raise brivaracetam levels. The clinical effect is likely small.
How serious is the interaction between Brivaracetam and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for dizziness and sedation and reduce the brivaracetam dose if they occur.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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