Drug interactions
Brivaracetam + Tramadol
Severity: Moderate
Brivaracetam and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and fatigue, so combined use may add to sedation and impair coordination. Tramadol can lower the seizure threshold, which may work against the antiseizure effect of brivaracetam in patients with epilepsy.
What this interaction means in plain words
Brivaracetam and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; tramadol pro-convulsant activity opposes antiseizure therapy.
What to do
Monitor for sedation and for any increase in seizure frequency. Consider a non-tramadol analgesic in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Tramadol?
MediHelp rates the interaction as moderate. Brivaracetam and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and fatigue, so combined use may add to sedation and impair coordination. Tramadol can lower the seizure threshold, which may work against the antiseizure effect of brivaracetam in patients with epilepsy.
How serious is the interaction between Brivaracetam and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for any increase in seizure frequency. Consider a non-tramadol analgesic in patients with epilepsy.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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