Drug interactions
Bromocriptine + Cabergoline
Severity: Moderate
Bromocriptine and Cabergoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are ergot-derived dopamine agonists, so combining them duplicates therapy and adds dopaminergic and ergot-related adverse effects such as hypotension, nausea and, with long-term use, fibrosis. There is rarely a reason to use both.
What this interaction means in plain words
Bromocriptine and Cabergoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Cabergoline belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects from two ergot-derived D2 receptor agonists.
What to do
Avoid concurrent use and choose one agent, adjusting its dose to effect. If switching, stop one before starting the other and monitor blood pressure and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Cabergoline
- Cabergoline + Promethazine Contraindicated
- Benperidol + Cabergoline Major
- Cabergoline + Chlorpromazine Major
- Cabergoline + Clarithromycin Major
- Cabergoline + Dexfenfluramine Major
- Cabergoline + Droperidol Major
Frequently asked questions
Can I take Bromocriptine with Cabergoline?
MediHelp rates the interaction as moderate. Bromocriptine and Cabergoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are ergot-derived dopamine agonists, so combining them duplicates therapy and adds dopaminergic and ergot-related adverse effects such as hypotension, nausea and, with long-term use, fibrosis. There is rarely a reason to use both.
How serious is the interaction between Bromocriptine and Cabergoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose one agent, adjusting its dose to effect. If switching, stop one before starting the other and monitor blood pressure and tolerability.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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