Drug interactions
Bromocriptine + Efavirenz
Severity: Moderate
Bromocriptine and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may alter bromocriptine exposure, and raised levels could cause hypotension, nausea or vasospasm. The effect of efavirenz on CYP3A4 is mixed and not well characterized for this pair.
What this interaction means in plain words
Bromocriptine and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz modulates CYP3A4 activity, which may change bromocriptine metabolism; the direction and extent are uncertain.
What to do
Monitor for ergot-type adverse effects and for loss of prolactin or motor control. Adjust bromocriptine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Efavirenz?
MediHelp rates the interaction as moderate. Bromocriptine and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may alter bromocriptine exposure, and raised levels could cause hypotension, nausea or vasospasm. The effect of efavirenz on CYP3A4 is mixed and not well characterized for this pair.
How serious is the interaction between Bromocriptine and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergot-type adverse effects and for loss of prolactin or motor control. Adjust bromocriptine dose according to response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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