Drug interactions
Bromocriptine + Erythromycin
Severity: Moderate
Bromocriptine and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can increase bromocriptine concentrations, leading to nausea, hypotension, headache, dizziness and other dopaminergic effects.
What this interaction means in plain words
Bromocriptine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated bromocriptine metabolism by erythromycin.
What to do
Monitor for dopaminergic adverse effects and lower the bromocriptine dose if they occur. Consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Erythromycin?
MediHelp rates the interaction as moderate. Bromocriptine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can increase bromocriptine concentrations, leading to nausea, hypotension, headache, dizziness and other dopaminergic effects.
How serious is the interaction between Bromocriptine and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dopaminergic adverse effects and lower the bromocriptine dose if they occur. Consider an alternative antibiotic.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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