Drug interactions
Bromocriptine + Istradefylline
Severity: Moderate
Bromocriptine and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at the 40 mg daily dose raises exposure to sensitive CYP3A4 substrates, and bromocriptine is cleared mainly by CYP3A4. Higher bromocriptine levels may increase dopaminergic adverse effects such as nausea, orthostatic hypotension, somnolence and dyskinesia.
What this interaction means in plain words
Bromocriptine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits intestinal and hepatic CYP3A4, reducing bromocriptine metabolism.
What to do
Monitor for dopaminergic adverse effects and consider a lower bromocriptine dose if istradefylline 40 mg/day is used. Reassess if the istradefylline dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Istradefylline
Frequently asked questions
Can I take Bromocriptine with Istradefylline?
MediHelp rates the interaction as moderate. Bromocriptine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at the 40 mg daily dose raises exposure to sensitive CYP3A4 substrates, and bromocriptine is cleared mainly by CYP3A4. Higher bromocriptine levels may increase dopaminergic adverse effects such as nausea, orthostatic hypotension, somnolence and dyskinesia.
How serious is the interaction between Bromocriptine and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dopaminergic adverse effects and consider a lower bromocriptine dose if istradefylline 40 mg/day is used. Reassess if the istradefylline dose changes.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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