Drug interactions
Bromocriptine + Ivosidenib
Severity: Moderate
Bromocriptine and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower bromocriptine concentrations, potentially reducing its therapeutic effect. This could affect control of prolactin levels, acromegaly or parkinsonian symptoms.
What this interaction means in plain words
Bromocriptine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases bromocriptine metabolism.
What to do
Monitor for loss of bromocriptine efficacy, such as prolactin level or symptom control, and increase the dose if needed. Reassess the dose after ivosidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Bromocriptine with Ivosidenib?
MediHelp rates the interaction as moderate. Bromocriptine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower bromocriptine concentrations, potentially reducing its therapeutic effect. This could affect control of prolactin levels, acromegaly or parkinsonian symptoms.
How serious is the interaction between Bromocriptine and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bromocriptine efficacy, such as prolactin level or symptom control, and increase the dose if needed. Reassess the dose after ivosidenib is stopped.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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