Drug interactions
Bromocriptine + Larotrectinib
Severity: Minor
Bromocriptine and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with limited inhibitory activity, so a clinically meaningful effect on bromocriptine is uncertain. Any increase in bromocriptine exposure is expected to be small.
What this interaction means in plain words
Bromocriptine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bromocriptine belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; not well established.
What to do
No routine adjustment is needed. Watch for dopaminergic adverse effects such as nausea or hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bromocriptine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Bromocriptine with Larotrectinib?
MediHelp rates the interaction as minor. Bromocriptine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with limited inhibitory activity, so a clinically meaningful effect on bromocriptine is uncertain. Any increase in bromocriptine exposure is expected to be small.
How serious is the interaction between Bromocriptine and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for dopaminergic adverse effects such as nausea or hypotension.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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