Drug interactions
Bromocriptine + Lorlatinib
Severity: Moderate
Bromocriptine and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may reduce bromocriptine concentrations. A weaker therapeutic effect could result.
What this interaction means in plain words
Bromocriptine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing bromocriptine metabolism.
What to do
Monitor prolactin levels or symptom control and raise the bromocriptine dose if the response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Bromocriptine with Lorlatinib?
MediHelp rates the interaction as moderate. Bromocriptine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A inducer and may reduce bromocriptine concentrations. A weaker therapeutic effect could result.
How serious is the interaction between Bromocriptine and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor prolactin levels or symptom control and raise the bromocriptine dose if the response declines.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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