Drug interactions
Brompheniramine + Caffeine
Severity: Minor
Brompheniramine and Caffeine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a stimulant and may partly offset the drowsiness caused by brompheniramine. The offset is incomplete and unpredictable, and it does not reliably restore psychomotor performance.
What this interaction means in plain words
Brompheniramine and Caffeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brompheniramine belongs to Respiratory; Caffeine belongs to Miscellaneous.
Why it happens
Caffeine's adenosine-receptor antagonism opposes sedation from H1 blockade; there is no significant pharmacokinetic interaction.
What to do
No action is generally needed. Do not rely on caffeine to counteract sedation when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brompheniramine
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Brompheniramine with Caffeine?
MediHelp rates the interaction as minor. Brompheniramine and Caffeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is a stimulant and may partly offset the drowsiness caused by brompheniramine. The offset is incomplete and unpredictable, and it does not reliably restore psychomotor performance.
How serious is the interaction between Brompheniramine and Caffeine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Do not rely on caffeine to counteract sedation when driving.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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