Drug interactions
Brompheniramine + Carbinoxamine
Severity: Moderate
Brompheniramine and Carbinoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation antihistamines, so using them together duplicates therapy and increases sedation and anticholinergic effects such as dry mouth, urinary retention and blurred vision. Older adults are particularly vulnerable to confusion.
What this interaction means in plain words
Brompheniramine and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Carbinoxamine belongs to Respiratory.
Why it happens
Additive H1 antagonism with additive central and peripheral anticholinergic effects.
What to do
Avoid concurrent use of two antihistamines and use only one agent. Check combination cold products for duplicate antihistamine content.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Brompheniramine with Carbinoxamine?
MediHelp rates the interaction as moderate. Brompheniramine and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation antihistamines, so using them together duplicates therapy and increases sedation and anticholinergic effects such as dry mouth, urinary retention and blurred vision. Older adults are particularly vulnerable to confusion.
How serious is the interaction between Brompheniramine and Carbinoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antihistamines and use only one agent. Check combination cold products for duplicate antihistamine content.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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