Drug interactions
Brompheniramine + Cariprazine
Severity: Moderate
Brompheniramine and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine and cariprazine can cause somnolence, so the combination may produce marked drowsiness and impaired psychomotor performance. Anticholinergic effects may also add up.
What this interaction means in plain words
Brompheniramine and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Cariprazine belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 receptor antagonism and antipsychotic receptor blockade.
What to do
Counsel patients to avoid driving and hazardous tasks while drowsy. Consider a non-sedating antihistamine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Cariprazine?
MediHelp rates the interaction as moderate. Brompheniramine and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine and cariprazine can cause somnolence, so the combination may produce marked drowsiness and impaired psychomotor performance. Anticholinergic effects may also add up.
How serious is the interaction between Brompheniramine and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and hazardous tasks while drowsy. Consider a non-sedating antihistamine instead.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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