Drug interactions
Brompheniramine + Chlordiazepoxide-clidinium
Severity: Moderate
Brompheniramine and Chlordiazepoxide-clidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine with anticholinergic activity. With chlordiazepoxide it increases drowsiness and impaired psychomotor function, and with clidinium it adds anticholinergic effects such as dry mouth, constipation and urinary retention.
What this interaction means in plain words
Brompheniramine and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Avoid or limit use, particularly in older adults. Counsel on sedation and anticholinergic effects and consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as moderate. Brompheniramine and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine with anticholinergic activity. With chlordiazepoxide it increases drowsiness and impaired psychomotor function, and with clidinium it adds anticholinergic effects such as dry mouth, constipation and urinary retention.
How serious is the interaction between Brompheniramine and Chlordiazepoxide-clidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit use, particularly in older adults. Counsel on sedation and anticholinergic effects and consider a non-sedating antihistamine.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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