Drug interactions
Brompheniramine + Chlorpheniramine
Severity: Moderate
Brompheniramine and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating first-generation antihistamines, so combining them duplicates therapy and increases drowsiness and anticholinergic effects.
What this interaction means in plain words
Brompheniramine and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Chlorpheniramine belongs to Respiratory.
Why it happens
Additive H1 antagonism with CNS depressant and anticholinergic effects.
What to do
Avoid using both together and choose a single antihistamine. Warn about impaired alertness if unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Chlorpheniramine?
MediHelp rates the interaction as moderate. Brompheniramine and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating first-generation antihistamines, so combining them duplicates therapy and increases drowsiness and anticholinergic effects.
How serious is the interaction between Brompheniramine and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together and choose a single antihistamine. Warn about impaired alertness if unavoidable.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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