Drug interactions
Brompheniramine + Chlorzoxazone
Severity: Moderate
Brompheniramine and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and the sedating antihistamine can add to the drowsiness caused by chlorzoxazone. This may impair alertness, driving and psychomotor performance.
What this interaction means in plain words
Brompheniramine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depression through pharmacodynamic synergy.
What to do
Warn the patient about drowsiness and advise against driving or operating machinery until the response is known. Consider a non-sedating antihistamine if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Chlorzoxazone?
MediHelp rates the interaction as moderate. Brompheniramine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and the sedating antihistamine can add to the drowsiness caused by chlorzoxazone. This may impair alertness, driving and psychomotor performance.
How serious is the interaction between Brompheniramine and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and advise against driving or operating machinery until the response is known. Consider a non-sedating antihistamine if sedation is troublesome.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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