Drug interactions
Brompheniramine + Cyclizine
Severity: Moderate
Brompheniramine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating antihistamines with anticholinergic activity, so combined use increases drowsiness and impairs alertness. Anticholinergic effects such as dry mouth, blurred vision and urinary retention are also more likely.
What this interaction means in plain words
Brompheniramine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Cyclizine belongs to Respiratory.
Why it happens
Additive central H1-receptor antagonism and muscarinic blockade.
What to do
Avoid concurrent use where possible. If needed, counsel on sedation and monitor older patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Brompheniramine with Cyclizine?
MediHelp rates the interaction as moderate. Brompheniramine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating antihistamines with anticholinergic activity, so combined use increases drowsiness and impairs alertness. Anticholinergic effects such as dry mouth, blurred vision and urinary retention are also more likely.
How serious is the interaction between Brompheniramine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If needed, counsel on sedation and monitor older patients for confusion and falls.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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