Drug interactions
Brompheniramine + Deutetrabenazine
Severity: Moderate
Brompheniramine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine can cause somnolence and sedation, which may be intensified by a sedating antihistamine. This can impair alertness and daily functioning.
What this interaction means in plain words
Brompheniramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from VMAT2 inhibition and H1 blockade.
What to do
Monitor for excessive sedation and advise caution when driving. Consider reducing the antihistamine dose or switching to a non-sedating agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Brompheniramine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Brompheniramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine can cause somnolence and sedation, which may be intensified by a sedating antihistamine. This can impair alertness and daily functioning.
How serious is the interaction between Brompheniramine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise caution when driving. Consider reducing the antihistamine dose or switching to a non-sedating agent.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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