Drug interactions
Brompheniramine + Lemborexant
Severity: Moderate
Brompheniramine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so concurrent use can enhance drowsiness and impair next-day alertness and coordination. The risk is higher at higher lemborexant doses.
What this interaction means in plain words
Brompheniramine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin antagonism and H1 receptor blockade.
What to do
Avoid concurrent sedating antihistamines where possible, or reduce the lemborexant dose if clinically needed. Counsel on next-day impairment and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Lemborexant
Frequently asked questions
Can I take Brompheniramine with Lemborexant?
MediHelp rates the interaction as moderate. Brompheniramine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so concurrent use can enhance drowsiness and impair next-day alertness and coordination. The risk is higher at higher lemborexant doses.
How serious is the interaction between Brompheniramine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent sedating antihistamines where possible, or reduce the lemborexant dose if clinically needed. Counsel on next-day impairment and driving.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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